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Skin rejuvenation with fibroblast stem cell therapy

What is fibroblast stem cell therapy?

Fibroblast stem cell therapy is an autologous fibroblast cellular therapy method obtained from the person’s own skin cells, which reverses the effects of time. Cellular therapies are part of tissue engineering. Stem cells are responsible for the regeneration of a damaged tissue.

What is autologous therapy?

The concept of “autologous treatment” defines the reproduction of one’s own tissue cells and placing them in the problem area. For example, in patients with extensive burns, tissues taken from the intact skin area are reproduced by tissue engineering and transferred to the burned area. On the other hand, heterologous treatment means person-to-person transplant and is mostly preferred in organ transplants.

In which areas is stem cell therapy used?

Tissue loss, especially in war, accident or birth, can be caused by chronic ulcers. non-healing wounds, acne scars, chickenpox scarsperiodontological applications in dentistry, baldness treatment, lip augmentation and wrinkle removalCulture-enhanced fibroblast treatment is a method frequently used in Europe and America in aesthetic applications for aesthetic purposes.

What are the advantages of stem cell therapy?

· Since it is produced from your own tissue, there are no risks such as tissue rejection, allergy or infection.

There is no risk of causing animal disease.

It is permanent and long-acting.

· It does not slip from the place where it is injected.

How is fibroblast stem cell therapy applied?

Preparation phase:

A lentil-sized biopsy is taken under sterile conditions under local anesthesia from the area of ​​the skin that is least exposed to external factors (usually behind the ear or in the arm). It is transferred to the biopsy transport solution and sent to a laboratory licensed by the Ministry of Health for cell production under aseptic conditions with a cold chain.

To prevent any allergic reaction, fibroblast production is done with the patient’s own serum. For this reason, some blood is taken from the patient during the biopsy and sent to the laboratory.

Fibroblast production stage:

This process takes about 4-6 weeks, depending on the tissue quality of the person.

Application phase:

When the cultured fibroblasts reach a sufficient number, the patient is given an appointment in the clinic. It is possible to produce an implant with a volume of 5-10 ml from a piece of skin the size of a lentil, with 10 million cells in 1 ml. 1-2 ml of this is used in the first injection. The remaining cells are stored in liquid nitrogen vapor with the gradual freezing technique.

Ready fibroblast culture is given by the physician by injection under the skin with fine needles. The application is repeated 3 times with an interval of 3-6 weeks.

When are the first effects seen after the application?

Although it varies from person to person, the first effects begin to become evident in 4-6 weeks after the 2nd injection.

How long is the effect of the application?

The healing process in the skin tissue continues gradually up to 12 months. This recovery is long lasting and protects itself for 4-5 years. If the patient wishes, the stored stem cells can be reproduced and transplanted at the end of this period.

What are the side effects that can be seen after the application?

Temporary swelling on the face, bruising at the injection points, and redness may occur.

Who cannot be treated with fibroblast stem cell therapy?

Pregnant women should be excluded from this study, as there is no study on pregnant women. In addition, those who have undergone previous cancer treatment are also not eligible for this study.

What is the superiority of fibroblast stem cell therapy over other methods?

While fillers provide temporary fullness, especially in skin wrinkles, in the short term, autologous fibroblast culture has a slower effect, but the persistence of the collagen produced by the transplanted fibroblasts is long-term, reconstructs the skin tissue and creates a more natural rejuvenation effect.

· Since it is produced from the person’s own tissue, there is no risk of side effects such as tissue rejection, allergy, infection, and it is safe.

Are stem cell therapy and PRP therapy the same?

No, although natural material taken from the person’s own body is used in both applications, the two methods are different from each other. In the treatment of PRP, clotting cells called platelets in the blood taken from the vein are used. Their main task is to stop the blood flowing and then to repair the wound. The stimulating factors required for this repair are found in the platelets and indirectly act on the stem cells and support them to produce more collagen. Fibroblast stem cell therapy is based on the principle of directly increasing the amount of stem cells in a certain area. Although the two methods are different, there is no harm in using both together.

What is the difference between stem cell therapy and mesotherapy?

When used for mesotherapy and rejuvenation, vitamins, hyaluronic acid and tissue recovery products are injected under the skin. These products are not natural tissue products, but are substances that nourish the skin. Although it is a classical method, the most important disadvantage is that it can cause allergies and its effectiveness is short-lived. Injections must be repeated at regular intervals to ensure a lasting effect.