Platelet-Rich Plasma (PRP) It is the return of a small amount of blood taken from the person with a special kit and the platelet-enriched plasma obtained after centrifugation to the same person by injection. The growth factors released from these cells activate the repair mechanisms of the cells and provide wound healing. In PRP application, much more platelets and growth factors can be delivered to the target area than can be carried by blood circulation. When platelets, which are concentrated in the plasma, are injected into the skin, they stimulate the production of collagen and the formation of new capillaries, and allow the skin to renew itself rapidly. The PRP process begins with blood collection from the patient, a special filter and the serum obtained by centrifuging at 3000 rpm in 8 minutes; It is injected into the skin with mesotherapy and filling method. The most important advantage of the method is that it is obtained from the patient’s own blood and does not carry the risk of allergy. Platelets and white blood cells at the injection site cause the release of intense growth factors with a synergistic effect.
Growth hormones, cytokines, chemokines and coagulation factors released from alpha and core granules in the platelets are the most important substances in hemostasis, wound healing and tissue regeneration. In order for these growth factors to take effect, they must be activated before they are released. Otherwise, damaged platelets will fail in this process. Platelets are found in normal blood at a value of approximately 140000-400000 per mm3. Different results in PRP applications; The equipment used, the protocol used to activate the platelet gel, the factors belonging to the patient, the amount of cells used, and different storage times.
A lot of research is being done on the growth factors in the content of platelets. There are even clinical applications of some growth factors. Apart from this, they are also included in cosmetic preparations.
PRP is a method that has been used medically for 30 years. It was used following open heart surgery in 1987. Today, orthopedic interventions, dental and oral interventions, plastic surgery flap shift surgeries, heart bypass surgeries are used in cases that require angiogenesis. Its first uses in dermatology are in the care of chronic wounds, ulcers and burns. In recent years, it has been widely used in the field of cosmetic dermatology.
We use PRP treatment in dermatology clinics;
1- In wound healing
2- In skin rejuvenation
3- Fine lines and wrinkles
4- In volumetric filling process
5- In acne scarring
6- In hair loss, which we call alopecia
7- In cellulite
8- We use it in the treatment of striae (skin cracks).
We prefer it to increase wound healing and get an effective result, especially after laser procedures on the face. The aim here is to stimulate the old and damaged skin and subcutaneous tissues, to renew them and to provide new skin production. In studies, good results have been shown in the treatment of the nasolabial fold, which extends from the edge of the nose to the corner of the mouth.
Success rates are high when combined with fractional lasers, especially in people who suffer from acne and have sunken scars. Since the TGF Beta 1 factor in the content of pregnancy spots we call melasma reduces the production of the color cell we call melanocyte, there is a field of application in the treatment. PRP, which was initially preferred because of strong and full hair growth after hair transplantation, is successfully applied in many hair loss types today. VEGF8 and PDGF4 substances in PRP are known to facilitate vascular formation and cause strong hair growth.
PRP is a method preferred by dermatologists because of its high tolerability, high level of skin rejuvenation, long-lasting effect, and new and natural collagen production.
Who is PRP treatment not applied to? We do not perform PRP in patients with critical platelet counts, hemodynamic disorders, sepsis, acute and chronic infections, facial (facial) malignancies, chronic liver pathology, and those receiving anticoagulant treatments.
We achieve positive results in hair loss such as Alopecia areata, Androgenic alopecia, Telogen efflivium, either alone or in combination with mesotherapy. We increase the success of treatment by combining laser treatments on skin spots. With these treatment protocols, which are combined with radiofrequency and laser, needle and needle-free mesotherapy methods alone in wrinkle and skin rejuvenation, we can ensure that your skin is healthy, shiny, skin elasticity is strong, and sagging problems are eliminated.
It is extremely important in terms of effectiveness that PRP treatment, which is frequently preferred by many dermatology groups and associations, in which I am a member, is preferred in dermatological and cosmetic applications. The side effects and complications that we have seen in the media about this application reveal the necessity of this procedure to be done by experts every day.
