Hair mesotherapy and drugs used

Mesotherapy is a treatment that potentially reduces the need for hair transplantation.

Mesotherapy techniques applied for hair loss have been developed from mesotherapy itself.

It can be called as approaches such as Mesoplasty or Mesohair. Positive effects on hair regrowth have been observed in both men and women.

Mesotherapy is neither complementary medicine nor alternative medicine. Since this application is intradermal or subcutaneous injection of pharmacological drugs, it is a technique of classical medicine.

Its purpose is to bring the area where the disease is located and the treatment application area closer to each other.

Selected drug mixtures are injected into the skin with special needles and special techniques in small doses locally. The dermis or hypodermis becomes the reservoir area, where the active substance is slowly released to where it needs to reach, via microcirculation. Therefore, this is a regional-local treatment method.

Scalp mesotherapy;It is a form of treatment that can be applied to the scalp at certain periods in order to stop hair loss, increase the quality of existing hair and activate new hair growth.

With special cocktails, especially vitamin supplements are made to the scalp and blood circulation to this area is improved. Increasing the blood supply to the hair follicles helps them to be better fed and developed.

The advantage of this method over other classical drug treatments is that the drugs are used in small doses locally. The risk of side effects is negligible and the results are effective.

Mesotherapy for hair growth uses different nutrients (such as biotin, hyaluronic acid and silica), vasodilators and androgen blockers. Weeks after the first application, it is observed that the hair grows again, after about six months, the spilled areas are revived and replaced with normal hair. The continuity of the applications at certain intervals is required.

Applications Generally in Mesotherapy;

  1. Intraepidermal application
  2. Superficial intradermal application
    • a-No injection (Nappaj – plastering)
    • b-Injected (Dot style, nappaj)
  3. Deep intradermal injection (Point style- PPP 1-4 mm )
  4. It can be done in the form of hypodermal injection (Point style – PPP 4-10 mm).

Drugs Used in Mesotherapy and Their General Properties

The agents used in practice form the basis of scalp mesotherapy. There is no fixed drug treatment in scalp mesotherapy. Substances with different mechanisms of action are administered alone or in combinations, depending on the pathology present in each patient. General principle; The aim is to avoid the combination of many agents in the formulations to be applied and to prepare the composition that can be beneficial to the pathology of the disease with the least substance.

The substances that can be used with mesotherapy can be classified as follows:

  • Local anesthetics: procaine, xylocaine
  • Vascular effects: buflomedil, melilate-rutin, pentoxifylline, gingko biloba, minoxidil paridyl heparin.
  • They are effective in stimulating the hair follicle and repairing the hair: X-ADN, amino acids, organic silicon.
  • Antiandrogen agents: finasteride, dutasteride, herbal extracts.
  • Antiseborrheic-anti-inflammatory effects: zinc, selenium, salicylate.
  • Effective for keratin biosynthesis: biotin, bepanthene, vitamin A, vitamin B group (such as pantothenic acid, vitamin B5), amino acids, oligoelements, zinc, copper, magnesium.

Standard ampoules and vials containing these agents are now available. Although agents such as minoxidil, finasteride, dutasteride, biotin, x-adn, organic silicon, d-panthenol can be found in their own names, there are also standard products (such as keractive, haircare) that contain different amino acids, vitamins and oligoelements in combination. These can be applied alone or in combinations.

The composition of the injected should not contain alcohol-based solvents that can cause skin necrosis. The composition should be isotonic, pH neutral, hypoallergenic and well tolerated locally. The most important point is to make a definitive diagnosis before starting the treatment and to choose the correct mixture to be injected.

Effect Mechanisms of Hair Mesotherapy and Purpose of Treatment

Cocktails made with these substances act at the level of the dermal papilla and regulate the production of keratin by stimulating hair growth and regeneration.

The vasodilator (vasodilator) substances in the cocktail increase the blood supply of the hair follicles by providing a functional microcirculation. Thus, they provide revitalization and thickening of the hair and shine. They control the mediators released from nerve endings.

Considering the 40% presence of blood cells of the immune system (immune system) in the mesoderm space, they try to prevent immune hair loss by affecting the immune unit.

Vitamins and elements in the cocktail prevent hair loss; they regulate oil secretion and reduce dandruff formation; contribute with their antioxidant properties.

As a result, the point reached; is the topical use of drugs in small doses. The risk of side effects is negligible and the treatment is more effective.

Scalp Mesotherapy Indications

  • In male pattern hair loss (androgenetic alopecia)
  • In cases of traction (due to pulling) spills on the forehead
  • In alopecia areata (ringworm)
  • In postpartum spills
  • In diffuse (general) spills seen mostly in women
  • It is applied in some scalp diseases (such as psoriasis, lichen, seborrheic dermatitis).
  • Early treatment is more effective in men.


Pregnant women, breastfeeding women, those with immunological diseases, cancer patients, diabetics, and those receiving anticoagulant treatment are not suitable patients.

There are some things to be considered before and after hair mesotherapy is applied.

What Should Be Done Before Mesotherapy?

  • The level of shedding should be determined by clinical examination.
  • Trichogram examination should be done.
  • The patient should be in the supine position.
  • Before the application, gloves should be worn and the area should be disinfected with an antiseptic solution. Alcohol, ether, chlorhexidine, betadine are preferred for skin disinfection.
  • Analgesic and anti-inflammatory applications should be discontinued 48 hours before.

What Should Be Done After Mesotherapy?

  • It is recommended to clean the skin with 70% ethyl alcohol after the treatment.
  • As a rule, hot showers should be avoided after the session in order not to increase the risk of allergy.
  • To prevent ecchymosis, post-session hemostasis should be done manually or with the weight of the patient.
  • Sessions should not be repeated at very frequent intervals. It may eliminate the beneficial effects of the previous session.